2-Hydroxyoleic Acid
نویسندگان
چکیده
منابع مشابه
2-hydroxyoleic acid: a new hypotensive molecule.
Recent studies have shown that diets rich in monounsaturated fatty acids (MUFAs) from olive oil, a natural source of oleic acid, have beneficial effects on blood pressure (BP) in hypertensive patients. With this in mind, we investigated whether a synthetic derivative of the MUFA oleic acid, 2-hydroxyoleic acid (2-OHOA), was capable of regulating the BP of Sprague-Dawley rats. Intraperitoneal an...
متن کاملThe mechanism of action of 2-hydroxyoleic acid (2OHOA),
Journal of Lipid Research Volume 54, 2013 1457 Copyright © 2013 by the American Society for Biochemistry and Molecular Biology, Inc. The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the specifi c and sequential induction of cell cycle arrest ( 1 ), cell differentiation ( 2 ), and cell death in human cancer cells ( 1–6 ). Based on its high effi cacy and l...
متن کاملNormalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells.
The very high mortality rate of gliomas reflects the unmet therapeutic need associated with this type of brain tumor. We have discovered that the plasma membrane fulfills a critical role in the propagation of tumorigenic signals, whereby changes in membrane lipid content can either activate or silence relevant pathways. We have designed a synthetic fatty acid, 2-hydroxyoleic acid (2OHOA), that ...
متن کامل2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner.
Monounsaturated fatty acids such as oleic acid are cardioprotective, modify the physicochemical properties of cardiomyocyte membranes, and affect the electrical stability of these cells by regulating the conductance of ion channels. We have designed a nonhydrolysable oleic acid derivative, 2-hydroxyoleic acid (2-OHOA), which regulates membrane lipid structure and cell signaling, resulting in be...
متن کاملThe anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport
2-hydroxyoleic acid (OHOA, Minerval®) is an example of a substance used for membrane lipid therapy, where the cellular membranes rather than specific proteins constitute the therapeutical target. OHOA is thought to mediate its anti-tumor effect by affecting the biophysical properties of membranes, which leads to altered recruitment and activation of amphitropic proteins, altered cellular signal...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2004
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000107778.85528.b5